Latest Publication:

  • Kazeminasab S, Taşkıran II, Fattahi Z, Bazzazzadegan N, Hosseini M, Rahimi M, Olaad Nabi M, Haddadi M, Çelik A, Ropers HH, Najmabadi H, and Kahrizi K

    CNKSR1 gene defect can cause syndromic autosomal recessive intellectual disability.

    American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(8):691-699
    The advent of high‐throughput sequencing technologies has led to an exponential increase in the identification of novel disease‐causing genes in highly heterogeneous diseases. A novel frameshift mutation in CNKSR1 gene was detected by Next‐Generation Sequencing (NGS) in an Iranian family with syndromic autosomal recessive intellectual disability (ARID). CNKSR1 encodes a connector enhancer of kinase suppressor of Ras 1, which acts as a scaffold component for receptor tyrosine kinase in mitogen‐activated protein kinase (MAPK) cascades. CNKSR1 interacts with proteins which have already been shown to be associated with intellectual disability (ID) in the MAPK signaling pathway and promotes cell migration through RhoA‐mediated c‐Jun N‐terminal kinase (JNK) activation. Lack of CNKSR1 transcripts and protein was observed in lymphoblastoid cells derived from affected patients using qRT–PCR and western blot analysis, respectively. Furthermore, RNAi‐mediated knockdown of cnk, the CNKSR1 orthologue in Drosophila melanogaster brain, led to defects in eye and mushroom body (MB) structures. In conclusion, our findings support the possible role of CNKSR1 in brain development which can lead to cognitive impairment.

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    Fly lab - Publications


    Selected Publications:

    • Çevrim BÇ, Mika K, Özturan G, Vulstreke V, Callaerts P, and Çelik A (2018) The cell adhesion molecule Unzipped mediates neuron-neuron and neuron-glia interactions to control mushroom body development. in revision Scientific Reports
    • Dereli Eke E, Arga KY, Dikicioglu D, Eraslan S, Erkol E, Çelik A, Kirdar B, and Di Camillo B (2019) Identification of Novel Components of Target-of-Rapamycin Signaling Pathway by Network-Based Multi-Omics Integrative Analysis OMICS: A Journal of Integrative Biology Published Online:13 April 2019 https://doi.org/10.1089/omi.2019.0021
    • Kazeminasab S, Taşkıran II, Fattahi Z, Bazzazzadegan N, Hosseini M, Rahimi M, Olaad Nabi M, Haddadi M, Çelik A, Ropers HH, Najmabadi H, and K Kahrizi K (2018) CNKSR1 gene defect can cause syndromic autosomal recessive intellectual disability. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 177(8):691-699. doi: 10.1002/ajmg.b.32648
    • Fattahi Z, Sheikh T, Musante L, Rasheed M, Taşkıran II, Harripaul R, Hu H, Kazeminasab S, Alam MR, Hosseini M, Larti F, Ghaderi Z, Çelik A, Ayub M, Ansar M, Haddadi M, Wienker TF, Ropers HH, Kahrizi K, Vincent JB, and H Najmabadi (2018) Biallelic missense variants in ZBTB11 can cause intellectual disability in human. Human Molecular Genetics 27(18):3177-3188. doi: 10.1093/hmg/ddy220.
    • Köstler S, Alaybeyoğlu B, Weichenberger CX, and Çelik A (2015) FlyOde – a platform for community curation and interactive visualization of dynamic gene regulatory networks in Drosophila eye development. F1000Research 4:1484-9.
    • Potier D, Davie K, Hulselmans G, Sanchez MN, Haagen L, Huynh-Thu VA, Koldere D, Çelik A, Geurts P, Christiaens V, and Aerts S (2014) Mapping gene regulatory networks in Drosophila eye development by large-scale transcriptome perturbations and motif inference. Cell Reports 9:1-14.
    • Mishra AK, Tsachaki M, Rister J, Shy D, Ng J, Çelik A, and Sprecher SG (2013) Binary cell fate decisions and fate transformation in the Drosophila larval eyeila. PLoS Genetics 9(12):e1004027.
    • Li X, Erclik T, Chen Z, Venkatesh S, Morante J, Çelik A, and Desplan C, (2013) Temporal specification of neuroblasts controls neuronal diversity in the Drosophila medulla. Nature 498(7455):456-62.
    • Vasiliauskas D, Mazzoni EO, Sprecher SG, Johnston RJ Jr, Lidder P, Vogt N, Çelik A, and Desplan C (2011) Feedback from Rhodopsin controls Rhodopsin exclusion in Drosophila R8 photoreceptors. Nature 479(7371):108-12.
    • Mazzoni EO, Çelik A, Wernet MF, Vasiliauskas D, Cook TA, Johnston RJ, Pichaud F, and Desplan C (2008) Iroquois-Complex genes induce co-expression of visual pigments in Drosophila. PLoS Biology 6(4):e9.
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      Primer:
      Stavenga DG, and Arikawa K (2008) One Rhodopsin per Photoreceptor: Iro-C Genes Break the Rule. PLoS Biology 6(4):e115.
    • Wernet MF, Çelik A, Mikeladze-Dvali T, and Desplan C (2007) Generation of uniform fly retinas. Current Biology 17(23):r1002-3.
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    • Wernet MF*, Mazzoni EO*, Çelik A*, Duncan DM, Duncan I, and Desplan C (2006) Stochastic spineless expression creates the retinal mosaic for colour vision. Nature 440(7081):174-180. *equal contribution
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      Featured in
      Faculty1000 ("9") and
      Hummel T, and Klaembt C (2006) Eye development: random precision in color vision. Current Biology 16(10):R361-R363.




    REVIEWS

    • Şahin HB, and Çelik A (2013) Drosophila eye development and photoreceptor specification eLS, John Wiley & Sons, Ltd: Chichester. DOI:10.1002/9780470015902.a0001147.pub2.
    • Morante J, Desplan C, and Çelik A (2007) Generating patterned arrays of photoreceptors. Current Opinion in Developmental Genetics 17(4):314-9. Review
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    • Fuss S, Çelik A, and Desplan C (2007) Olfactory identity kicked up a Notch. Nature Neuroscience 10(2):138-140. News&Views
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    • Mazzoni EO, Desplan C, and Çelik A (2004) 'One receptor' rules in sensory neurons. Developmental Neuroscience 26(5-6):388-95. Review
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    BOOK CONTRIBUTIONS

    • A. Çelik ve Wernet, M.F.W., Editors, "Decoding Neural Circuit Structure and Function: Cellular Dissection Using Genetic Model Organisms," Springer Verlag GmbH DOI 10.1007/978-3-319-57363-2
 ISBN 978-3-319-57362-5
 ISBN 978-3-319-57363-2 (eBook)
 15.07.2017.
    • Scott F. Gilbert, "Gelişim Biyolojisi, Bölüm 7, Amfibiler ve Balıklar: Erken gelişim ve eksen oluşumu," Çeviri: Arzu Çelik, 2013, Nobel Kitapevi.

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